2015 Foundation grant recipients
The Foundation Grants program provides Canada's top researchers with stable, long-term funding so that they can focus on ambitious, high-impact programs of research. Visit the Featured Research page to learn more about these researchers and their work.
The table below lists the recipients from the inaugural Foundation grant competition. For more information about the competition, visit the Funding Decisions Notification.
Notice
Project titles are provided in the language used by the researcher on the grant application.
| Principal investigator | Project title | Institution paid | Region |
|---|---|---|---|
| Lam, Wan L | An integrative approach to understand lung cancer development in smokers and non-smokers | University of British Columbia | BC |
| Lam, Tony K | Metabolic Impact of Nutrient Sensing-dependent Neuronal Mechanisms in the Gut and the Brain | University Health Network | ON |
| Dilworth, F J | Epigenetic Regulation of Muscle Regeneration in Health and Disease | Ottawa Hospital Research Institute | ON |
| Zhong, Toni | Development of a National Quality Improvement Program in Postmastectomy Breast Reconstruction to Optimize Patient-Centred Experience. | University Health Network | ON |
| Charron, Frederic | Shh signaling in normal and pathological nervous system development | Institut de recherches cliniques de Montréal | QC |
| Gingras, Anne-Claude | Functional proteomics of signaling in health and disease | Mount Sinai Hospital | ON |
| Mcneill, Helen | Coordinating tissue growth and tissue organization: Fat cadherins and the Hippo kinase pathway | Mount Sinai Hospital | ON |
| Stukel, Therese A | Measuring and Evaluating the Performance of integrated Health Systems for Complex Chronic Disease Patients | Sunnybrook Research Institute | ON |
| Brown, Eric D | Understanding and Subverting Bacterial Survival Strategies | McMaster University | ON |
| Sin, Donald | Using Multi-Omics To Discover Novel Biomarkers and Therapeutic Targets for Chronic Obstructive Pulmonary Disease | University of British Columbia | BC |
| Murphy, Timothy H | Enabling novel circuit-based treatments for stroke: insights from cortical circuit monitoring and manipulation in mouse models. | University of British Columbia | BC |
| Li, Ren-Ke | Rejuvenation of aged cells and recipients to enhance cardiac regeneration and prevent progressive heart failure | University Health Network | ON |
| Graham, Ian D | Moving knowledge into action for more effective practice, programs and policy: A research program focusing on integrated knowledge translation | University of Ottawa | ON |
| Knoll, Gregory | A Research Program to Improve Patient Outcomes in Kidney Transplantation | Ottawa Hospital Research Institute | ON |
| Zatorre, Robert J | Auditory Cognitive Neuroscience: Pathways, Processes, Plasticity and Predispositions | McGill University | QC |
| Zamponi, Gerald W | Voltage gated calcium channels: molecular targets for pain therapeutics | University of Calgary | AB |
| Wood, Evan | Positioning Canada as an international leader in addiction research and education to improve care and reduce costs to the health care system | University of British Columbia | BC |
| Peters, Terence M | Program for Image-guided Minimally Invasive Surgery and Therapy (PI-MIST) | University of Western Ontario | ON |
| Eng, Janice J Researcher profile |
Optimizing and maintaining abilities after stroke | University of British Columbia | BC |
| Marette, André | Pathogenesis and treatment of obesity-linked inflammation, insulin resistance and cardiometabolic complications | Université Laval | QC |
| Divangahi, Maziar | Regulation of Anti-Microbial Macrophage Response to Pulmonary Infections | Research Institute of the McGill University Health Centre | QC |
| Sicheri, Frank | Structural Principles of Signal Transduction | Mount Sinai Hospital | ON |
| Dedhar, Shoukat R | The Role of Tumor Microenvironment in Cancer Progression: Identification and Therapeutic Intervention of Novel Targets | University of British Columbia | BC |
| Shoichet, Molly S | Polymeric Biomaterials for Applications in Medicine | University of Toronto | ON |
| Sauvageau, Guy | Chemical and Genetic Interrogation of Human HSC Self-Renewal: Towards Optimal Cord Blood Grafts | Université de Montréal | QC |
| Bercik, Premysl Collins, Stephen M |
Microbiome and gut-brain axis: A translational approach for intestinal and neuropsychiatric diseases. | McMaster University | ON |
| Zwicker, Jill G | Using Brain Imaging to Determine Predictors of Developmental Coordination Disorder and Response to Intervention | University of British Columbia | BC |
| Bader, Gary D | From correlation to causation in genomics: identifying mechanisms underlying disease | University of Toronto | ON |
| Schulz, Richard (Rick) | Matrix metalloproteinases in cardiovascular health and disease: from bench to bedside | University of Alberta | AB |
| Zwaigenbaum, Lonnie Bryson, Susan E Researchers profile |
A Foundation Grant to Improve Early Detection, Diagnosis, and Treatment of Autism Spectrum Disorder | University of Alberta | AB |
| Prentki, Marc Researcher profile |
Lipid metabolism, insulin secretion and energy homeostasis | Centre hospitalier de l'Université de Montréal (CHUM) | QC |
| Granville, David J | Granzymes in Tissue Injury, Inflammation and Repair | University of British Columbia | BC |
| Miller, Freda D | From stem cells to circuitry: building and rebuilding the mammalian nervous system | Hospital for Sick Children | ON |
| Craig, Ann Marie | Molecular analysis of synapse development | University of British Columbia | BC |
| Thebaud, Bernard | Clinical translation of stem cell-based therapies for neonatal lung diseases | Ottawa Hospital Research Institute | ON |
| Andrews, Brenda J | Systems Genetics & Cell Biology: Mapping Biological Pathways in the Eukaryotic Cell | University of Toronto | ON |
| Schiffrin, Ernesto L | Vascular remodeling in hypertension and cardiometabolic disease: from mice to humans | Jewish General Hospital | QC |
| Naugler, Christopher | Misutilization of laboratory tests: pathways to correction | University of Calgary | AB |
| Scherer, Stephen W Researcher profile |
Genomes to Outcomes in Autism Spectrum Disorders | Hospital for Sick Children | ON |
| Anand, Sonia S | Deciphering the causes of, and developing interventions to reduce, cardio-metabolic risk factors among ethnic groups in Canada | McMaster University | ON |
| Jung, Mary E | Self-Regulation of Exercise Behaviour in Individuals with Prediabetes: From Evidence to Community Implementation | University of British Columbia | BC |
| Azoulay, Laurent | Cancer pharmacoepidemiology: a population-based assessment of the risks of prescription drugs in vulnerable populations | Jewish General Hospital | QC |
| Frayne, Richard | Quantitative MR Imaging of Vascular Contributions to Aging, Cognitive Decline and Stroke | University of Calgary | AB |
| Sareen, Jitender | Defining the Longitudinal Course, Outcomes, and Treatment Needs of Vulnerable Canadians with Posttraumatic Stress Disorder. | University of Manitoba | MB |
| Cohen-Adad, Julien | Shifting the paradigm of spinal cord quantitative MRI | École polytechnique de Montréal | QC |
| Booth, Gillian L | Building Healthier Cities: a Canadian Initiative To Identify Environmental Solutions to curb obesity (The 'Healthy Cities, Healthier Lives' Research Program) | St. Michael's Hospital | ON |
| Chertkow, Howard M | Typical and atypical Alzheimer Disease: salivary tau biomarkers, therapy with neuromodulation, and disease subtypes. | Jewish General Hospital | QC |
| Marra, Marco A | Exploring the relationship between the genome and the epigenome in cancers | University of British Columbia | BC |
| Lye, Stephen J | Pregnancy Complications and Developmental Health: Mechanisms, Diagnostics and Therapeutics. | Mount Sinai Hospital | ON |
| Raymond, Lynn A | Aberrant NMDA receptor and synaptic signaling in vulnerability to neurodegeneration: Focus on Huntington disease | University of British Columbia | BC |
| Rottapel, Robert K | The Architecture of Feedback Signaling Networks in Normal and Cancer Cells | University Health Network | ON |
| Gill, John S | Strategies to achieve self-sufficiency in kidney transplantation in Canada | University of British Columbia | BC |
| Slutsky, Arthur S Zhang, Haibo |
Mechanisms and Therapies of ARDS | St. Michael's Hospital | ON |
| Yokota, Toshifumi | Development of Novel Therapy for Neuromuscular Diseases | University of Alberta | AB |
| Brisson, Marc Researcher profile |
Using mathematical modeling and health economics to evaluate and optimize infectious disease prevention strategies | Université Laval | QC |
| Pike, G. Bruce | Quantitative Magnetic Resonance Imaging of Brain Structure and Function | University of Calgary | AB |
| Hakem, Razqallah | Investigation of the crosstalk of DNA Double strand break signaling/repair with Notch and Wnt signaling pathways; and determination of their roles in cancer development and therapies. | University Health Network | ON |
| Shah, Sohrab P | The clonal dynamics of ovarian cancers: phylogenetic models of chemosensitivity and resistance | University of British Columbia | BC |
| Beier, Frank | Molecular Pathways Driving Osteoarthritis | University of Western Ontario | ON |
| Grady, Cheryl L | Exploring the role of the frontoparietal control network across the adult lifespan | Baycrest Centre for Geriatric Care | ON |
| Ogilvie, Gina S | Integrated global control and prevention of HPV related diseases and cancer | University of British Columbia | BC |
| Lehoux, Pascale N | Responsible innovation in health: Designing technologies for sustainable healthcare systems | Université de Montréal | QC |
| Côté, Jacques | Control of Genome Expression and Maintenance by MYST-ING Tumor Suppressor Complexes. | Université Laval | QC |
| Barnabe, Cheryl C Researcher profile |
Arthritis care for indigenous populations | University of Calgary | AB |
| Klein, Marina B | Tracking a revolution: Evaluating the impact of modern HCV therapy on HIV-HCV coinfection | Research Institute of the McGill University Health Centre | QC |
| Malkin, David D | Molecular Determinants of the Li-Fraumeni Syndrome | Hospital for Sick Children | ON |
| O'Connor, Deborah L Unger, Sharon Researchers profile |
Maximizing Mothers' Milk for Preterm Infants (MaxiMoM) | Hospital for Sick Children | ON |
| Franco, Eduardo L Coutlée, François |
Research Program on the Epidemiology and Prevention of Human Papillomavirus Infection and Associated Cancers | McGill University | QC |
| James, Matthew T | Better Prediction and Decision Support Tools to Improve Care and Outcomes for Patients with Acute Kidney Injury (AKI) | University of Calgary | AB |
| Stergiopoulos, Vicky | Improving Mental Health Care for High Risk and Disadvantaged Populations: Evidence to Inform Policy and Practice | St. Michael's Hospital | ON |
| Afifi, Tracie O Researcher profile |
Preventing Child Maltreatment: Changing a Child's Trajectory, Improving Health, and Strengthening Families. | University of Manitoba | MB |
| Kahn, Susan R | Improving long term outcomes after venous thromboembolism (VTE) | Jewish General Hospital | QC |
| Yip, Calvin K | Molecular mechanisms of autophagy regulation | University of British Columbia | BC |
| Schurr, Erwin A | Host genetic dissection of mycobacterial infection phenotypes | Research Institute of the McGill University Health Centre | QC |
| Rachubinski, Richard A | Peroxisomes in Health and Disease | University of Alberta | AB |
| Ohashi, Pamela S | Regulating CD8 immunity and tumor immunity | University Health Network | ON |
| Yusuf, Salim Researcher profile |
Prospective Urban Rural Epidemiology (PURE) Program: causes, consequences, and impact of health systems for CVD and other NCDs | McMaster University | ON |
| Andrews, David W | Assembly of apoptotic as well as additional protein complexes on sub-cellular membranes | Sunnybrook Research Institute | ON |
| Harper, Mary-Ellen | Mitochondrial Bioenergetics and Redox Biology in Obesity and Related Disease | University of Ottawa | ON |
| Benchimol, Eric I | The Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC): Inflammatory Bowel Disease in Canada | Children's Hospital of Eastern Ontario | ON |
| Menzies, Richard | Tackling the two greatest obstacles to Tuberculosis elimination: Treatment of latent infection and drug resistant disease. | Research Institute of the McGill University Health Centre | QC |
| Grinstein, Sergio | The cell physiology of innate immunity: signal transduction, ion transport and membrane traffic. | Hospital for Sick Children | ON |
| Tarnopolsky, Mark A Researcher profile |
Characterization of novel exersomes that mediate the systemic pro-metabolic effects of exercise in aging and neuromuscular disorders. | McMaster University | ON |
| Shannon, Kate | Structural Determinants, Sexual Health and HIV/AIDS: Reducing Health & Social Inequities | University of British Columbia | BC |
| Yeates, Keith O | Advancing Concussion Assessment and Treatment in Children and Youth | University of Calgary | AB |
| Pibarot, Philippe J | Novel Approaches for the Diagnosis and Treatment of Aortic Valve Stenosis | Université Laval | QC |
| Frankland, Paul W | Memory function and dysfunction | Hospital for Sick Children | ON |
| Petrides, Michael | Comparative functional and anatomical study of human and monkey cortex | McGill University | QC |
| Bombard, Yvonne Researcher profile |
Integrating genomic technologies in health care: evidence, values and health policy | St. Michael's Hospital | ON |
| Bourque, Charles W | Central control of osmoregulation in health and disease | Research Institute of the McGill University Health Centre | QC |
| Iyer, Srividya N Malla, Ashok K |
Enhancing youth mental health: A program of research into mental healthcare needs, pathways, outcomes and services | Douglas Hospital Research Centre | QC |
| Ehrlicher, Allen J | Cellular mechanotransduction in the actin cytoskeleton. | McGill University | QC |
| Kirton, Christopher A Researcher profile |
The Alberta Perinatal Stroke Program: Neuromodulation to Optimize Outcomes | University of Calgary | AB |
| Grimshaw, Jeremy M | Promoting implementation of evidence-based care | Ottawa Hospital Research Institute | ON |
| Pukatzki, Stefan | Microbial Competition in Disease: Mechanisms and Applications | University of Alberta | AB |
| Nicholls, Tonia L | Violence, Victimization, and Crime among Marginalized Populations: Research to Advance Care and Management | University of British Columbia | BC |
| Dagher, Alain | Functional Neuroimaging of dopamine systems: application to Parkinson's Disease, addiction and obesity. | McGill University | QC |
| Alary, Michel | Vers des approches plus efficientes en prévention du VIH et en santé reproductive au travers une approche d'équité en santé: programme de recherche interventionnelle chez les femmes travailleuses du sexe en Afrique de l'Ouest. | Université Laval | QC |
| Strynadka, Natalie C Researcher profile |
Structure-based Antibiotic Discovery on the Bacterial Membrane | University of British Columbia | BC |
| Cullen, Kathleen E | Program of investigating vestibular physiology and its disorders | McGill University | QC |
| Pickering, J. Geoffrey | Vascular aging, repair, and regeneration | University of Western Ontario | ON |
| Lix, Lisa M | Advancing the Science of Data Quality for Electronic Health Databases: Applications to Chronic Disease Research and Surveillance | University of Manitoba | MB |
| Cook, Deborah J | Improving Outcomes Of Critically Ill Patients | McMaster University | ON |
| Watts, Tania H | Regulation of immunity by TNFR family members: from mechanisms of viral control to biomarkers of therapeutic outcome | University of Toronto | ON |
| Boone, Charles M | Principles of Global Genetic Interaction Networks | University of Toronto | ON |
| Lerch, Jason P Henkelman, R. Mark |
Imaging of normal and abnormal brain development in mice and humans. | Hospital for Sick Children | ON |
| Post, Martin | Lung Development, Injury and Repair | Hospital for Sick Children | ON |
| Rouleau, Guy A | Genetic & Biological Studies of Brain Disorders | McGill University | QC |
| Boilard, Eric Researcher profile |
Platelets and their microparticles: versatile players of inflammation | Université Laval | QC |
| Herzog, Walter | Cellular and Molecular Biomechanics of the Musculoskeletal System | University of Calgary | AB |
| Hogg, Robert S | Expansion of Antiretroviral Therapy and its Impact on Vulnerable Populations in Canada and Global Settings | Simon Fraser University | BC |
| Ford, James D Researcher profile |
A research program on adaptation to the health effects of climate change in the Canadian Arctic | McGill University | QC |
| Kubes, Paul | The interplay between subtypes of neutrophils, monocytes, macrophage, iNKT cells and platelets in infection, sterile injury and metastasis in the liver and other organs | University of Calgary | AB |
| Germain, Lucie | Les cellules souches épithéliales et le génie tissulaire : de la recherche fondamentale à la recherche clinique | Université Laval | QC |
| Mishra, Sharmistha | Mathematical Modeling and Epidemiology to inform HIV Program Science | St. Michael's Hospital | ON |
| Tu, Jack V | The CANHEART Study: Using big data to transform the prevention and management of cardiovascular diseases | Sunnybrook Research Institute | ON |
| Durocher, Daniel Researcher profile |
DNA double-strand break responses in health and disease | Mount Sinai Hospital | ON |
| Lester, Richard T Researcher profile |
Evidence to action for Canadian and global mobile health (mHealth) communication to promote patient engagement in care: a rigorous implementation science approach | University of British Columbia | BC |
| Devereaux, Philip J | Predicting and preventing the major vascular complications of surgery | McMaster University | ON |
| Rivest, Serge | Therapeutic properties of innate immune cells and system for brain diseases. | Université Laval | QC |
| Hegele, Robert A | Clinical translation of genomic understanding of cardiometabolic risk | University of Western Ontario | ON |
| Seuntjens, Jan P | Monte Carlo techniques in the optimization of radiation therapy delivery and outcomes | Research Institute of the McGill University Health Centre | QC |
| Cohen, Eyal | Health Outcomes of Children with Medical Complexity and their Caregivers | Hospital for Sick Children | ON |
| Ruthazer, Edward S | Cellular and molecular mechanisms underlying activity-dependent neural circuit development | McGill University | QC |
| Platt, Robert W | Statistical Methods in Pharmacoepidemiology and Perinatal Epidemiology | Research Institute of the McGill University Health Centre | QC |
| Philpott, Dana J | Innate immune regulation of intestinal homeostasis: insight into Crohn's disease pathogenesis. | University of Toronto | ON |
| Mak, Tak W | Dissection of Tumorigenic and Inflammatory Signaling Pathways to Identify Novel Therapeutic Approaches | University Health Network | ON |
| Hill, Matthew N | Corticolimbic Endocannabinoid Signaling and the Regulation of Stress and Anxiety | University of Calgary | AB |
| Leung, Peter C | Hormonal determinants of women's reproductive health and disease | University of British Columbia | BC |
| Tonelli, Marcello | Patient-centred care of comorbidity for people with chronic kidney disease | University of Calgary | AB |
| Stiell, Ian G Researcher profile |
Improving Care for Emergency Department and Pre-Hospital Patients with Acute and Life-Threatening Conditions | Ottawa Hospital Research Institute | ON |
| Woodgett, James (Jim) R | Genetic analysis of signal transduction pathways involved in human diseases. | Mount Sinai Hospital | ON |
| Maguire, Jonathon L | TARGet Kids!: Optimizing Human Potential | St. Michael's Hospital | ON |
| Rak, Janusz | Targeting vascular mechanisms of cancer progression | Research Institute of the McGill University Health Centre | QC |
| Gotman, Jean | Electrical and metabolic manifestations of human focal epilepsy | McGill University | QC |
| Klip, Amira | Cell biology and physiology of muscle insulin delivery, insulin action and insulin resistance leading to diabetes | Hospital for Sick Children | ON |
| Veillette, André | Genetic and molecular studies of lymphocyte activation, immunodeficiencies and autoimmunity | Institut de recherches cliniques de Montréal | QC |
| Szatmari, Peter | Pathways to Better Developmental Health in Autism Spectrum Disorder: Phase III | Centre for Addiction and Mental Health | ON |
| Lupien, Sonia J Researcher profile |
Stress and the Power of Others : Generating New Knowledge and Translating it Into Successful Education Programs | Institut universitaire en santé mentale de Montréal | QC |
| Park, Morag | Mechanisms of Met activation in cancer and therapeutic intervention | McGill University | QC |
| Duncan, Roy Researcher profile |
Viral membrane fusion machines: evolution, applications, mechanism-of-action and pathogenic implications | Dalhousie University (Nova Scotia) | NS |
| Rossant, Janet Researcher profile |
Making the blastocyst; from lineage specification to stem cells to stem cell therapies | Hospital for Sick Children (Toronto) | ON |
| Sorensen, Poul H | Targeting the tumour cell stress response in high-risk childhood cancers | University of British Columbia | BC |
| Stewart, Duncan J | From endothelial biology to meaningful clinical impact | Ottawa Hospital Research Institute | ON |
| Wheeler, Michael B | Pancreatic Beta Cell Health and Diabetes | University of Toronto | ON |
| Wrana, Jeffrey L | Morphogen Signalling in Development and Disease | Mount Sinai Hospital (Toronto) | ON |
| Archer, Stephen L | Mitochondrial Dynamics and Metabolism in Pulmonary Arterial Hypertension | Queen's University | ON |
| Nagy, Andras | Somatic cell reprogramming and therapeutics | Mount Sinai Hospital (Toronto) | ON |
| Julien, Jean-Pierre | From pathogenic pathways to novel therapeutic strategies in amyotrophic lateral sclerosis | Université Laval | QC |
| Kieffer, Timothy J | Hormonal Regulation of Glucose Homeostasis | University of British Columbia | BC |
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