Inflammation in Chronic Disease

Phase 1

In recognition of the key role that inflammation plays in multiple chronic diseases, CIHR launched the Inflammation in Chronic Disease initiative aimed at understanding commonalities and differences between these chronic diseases with respect to the role that inflammation plays in their development, progression and complications. The vision of CIHR's Inflammation in Chronic Disease initiative, which was developed at the 2011 Inflammation in Chronic Disease Consensus Conference, was to establish new interdisciplinary teams that bring together groups of researchers who could undertake innovative research in the field of chronic inflammation. The Inflammation in Chronic Disease initiative also encompasses two other CIHR research initiatives, the Canadian Microbiome Initiative and the Transplantation Research Initiative.

Phase 2

Building on previous investments, CIHR has now launched the Health Challenges in Chronic Inflammation – Phase 2 (HCCI2) initiative.

• Overview of HCCI2
• HCCI2 Strategic Funding Opportunities
• Funding results
  • Team Grants: Preparation to Trial: Inflammation for Chronic Conditions
  • Team Grants: Preparation to Trial in Inflammation for Chronic Conditions - CIHR HIV/AIDS Research Initiative
  • Team Grant: Intervention Trial in Inflammation for Chronic Conditions
  • Team Grant: Intervention Trial in Inflammation for Chronic Conditions – CIHR HIV/AIDS Research Initiative
  • Team Grant: Intervention Trial in Inflammation for Chronic Conditions – Knowledge Mobilization Hub

Team Grant: Preparation to Trial: Inflammation for Chronic Conditions

Name	Institution	Project title
Levings, Megan K Dijke, Ilona E West, Lori J	University of British Columbia	Allogeneic thymus-derived Tregs to prevent chronic inflammation in transplantation
Muruve, Daniel A Kubes, Paul Senger, Donna L	University of Calgary	Therapeutic Targeting a Shared Inflammation Pathway in the Lung and Kidney
Rayner, Katey	Ottawa Heart Institute Research Corporation (Ontario)	Targeting RIPK1 in Immunometabolism and Cardiovascular Diseases (TRIC)
Schultz, Kirk R	University of British Columbia	Regulatory Natural Killer Cell Treatment in Chronic Graft-versus-Host Disease and Solid Organ Transplantation Chronic Rejection
Swardfager, Walter L Lanctôt, Krista L	Sunnybrook Research Institute (Toronto, Ontario)	Pro-Resolving Inflammatory Mediators in Neurovascular Gains in Aerobic Training (PRIMiNG-AT)

Team Grant: Preparation to Trial in Inflammation for Chronic Conditions - CIHR HIV/AIDS Research Initiative

Name	Institution	Project title
Costiniuk, Cecilia T Di Marzo, Vincenzo Jenabian, Mohammad-Ali	Research Institute of the McGill University Health Centre	Role of the Endocannabinoid System (ECS) in HIV-associated chronic inflammation and comorbidities
Mckinnon, Lyle R Arsenio, Janilyn Murooka, Thomas T	University of Manitoba	Subsets of subsets: investigating Th17 pathways in inflammatory bowel disease and HIV

Team Grant: Intervention Trial in Inflammation for Chronic Conditions

Name	Institution	Project title
Levings, Megan K Schultz, Kirk R Ahmad, Imran Dijke, Ilona E Hay, Kevin A Lad, Deepesh P West, Lori J	University of British Columbia	Allogeneic regulatory T cell therapy to prevent graft versus host disease
James, Matthew T Levin, Adeera Pannu, Neesh I	University of Calgary	Prevention of Nephrotoxin-induced Acute Kidney Injury with Cilastatin (PONTIAC) Trial
Katsanos, Aristeidis Shoamanesh, Ashkan	McMaster University	Colchicine for the prevention of vascular events after an acute intracerebral hemorrhage (CoVasc-ICH)

Team Grants: Intervention Trial in Inflammation for Chronic Conditions – CIHR HIV/AIDS Research Initiative

Name	Institution	Project title
Durand, Madeleine Margolese, Shari L Finzi, Andrés	Centre hospitalier de l'Université de Montréal (CHUM)	The RESTART Trial: Reducing Systemic inflammation for people on AntiRetroviral Therapy

Team Grants: Intervention Trial in Inflammation for Chronic Conditions – Knowledge Mobilization Hub

Name	Institution	Project title
Gongal, Patricia Levings, Megan K West, Lori J	University of Alberta	A Knowledge Mobilization Hub for the Canadian Inflammation Research Community

Date modified:

2025-02-05