Pre-announcement – Team Grants: Preparation to Trial in Inflammation for Chronic Conditions

CIHR and its Institutes of Infection and Immunity, Aging, Circulatory and Respiratory Health, Gender and Health, Musculoskeletal Health and Arthritis, Nutrition, Metabolism and Diabetes and CIHR HIV/AIDS Research Initiative in collaboration with Mitacs, Cystic Fibrosis Canada and adMare BioInnovations are pleased to announce the upcoming funding opportunity for Team Grants: Preparation to Trial in Inflammation for Chronic Conditions.

Description

Although early immune or metabolic events result in inflammation specific to a given condition, they result in the activation of shared mechanistic pathways of inflammation that lead to the development of symptoms and co-morbidities shared among chronic conditions^{Footnote 1}. Leveraging our collective understanding of shared pathways of inflammation across chronic conditions will help address a critical gap in the development of interventions and the clinical translation of research to improve prevention, diagnosis, and management of inflammation.

Building on the shared framework for inflammation research initiated, CIHR Health Challenges in Chronic Inflammation Phase 2 (HCCI2) Initiative will support a collaborative and inter-disciplinary strategy on inflammation to accelerate the development of new solutions, and the repurposing and optimization of existing solutions for the prevention, diagnosis, prediction of treatment response, and management of inflammation in chronic conditions. Interventions are to target biological, environmental, social and behavioral triggers of shared pathways of inflammation across two or more chronic conditions relevant to any of the CIHR Institutes and/or Initiatives collaborating on this funding opportunity.

This funding opportunity is the first of two that are part of the CIHR Health Challenges in Chronic Inflammation Phase 2 (HCCI2) Initiative and will support the advancement of preclinical research towards the human intervention trial stage and/or a better understanding of the implementation context to enable the scale up of existing interventions.

Objectives

The objectives of the Team Grants: Preparation to Trial in Inflammation for Chronic Conditions funding opportunity are to promote:

• application of new and existing knowledge on shared pathways that drive inflammation in chronic conditions to be targeted in subsequent human intervention trials;
• precision medicine approach that equitably delivers the benefit of interventions and improves health outcomes for all individuals; and,
• high quality, inter-disciplinary training and mentoring environment to prepare the next generation of leaders in inflammation research.

Funds available

CIHR and partner financial contributions for this initiative are subject to availability of funds. Should funding levels not be available or are decreased due to unforeseen circumstances, CIHR and its partners reserve the right to reduce, defer or suspend financial contributions to grants received as a result of this funding opportunity.

The total amount available for this funding opportunity is $5,250,000 enough to fund approximately seven (7) grants. The maximum amount per grant from CIHR is $250,000 per year for up to 3 years, for a total of $750,000 per grant.

Additional competition partner funding is available from Mitacs to fund graduate and postdoctoral internships.

Anticipated Timelines*

* These timelines are estimates and subject to change.

Date modified:

2021-02-02